Ivar Järving, PhD
Ivar is a leading expert in aseptic processing of pharmaceuticals in Estonia, having 20 years of experience in this field.
Ivar has studied chemical engineering at Tallinn University of Technology, he obtained his PhD in the field of bioorganic chemistry.
He has been mainly involved in the discovery and research of dioxygenases and synthesis of eicosanoids.
He is an author of more than 50 scientific publications in international journals.
RECENT PUBLICATIONS
Ošeka M, Kimm M, Kaabel S, Järving I, Rissanen K, Kanger T. Asymmetric Organocatalytic Wittig [2,3]-Rearrangement of Oxindoles. Org Lett. 2016 Mar 18;18(6):1358-61.
Eek P, Piht MA, Rätsep M, Freiberg A, Järving I, Samel N. A conserved π-cation and an electrostatic bridge are essential for 11R-lipoxygenase catalysis and structural stability. Biochim Biophys Acta. 2015 Oct;1851(10):1377-82.
Lippur K, Kaabel S, Järving I, Rissanen K, Kanger T. CaCl2, Bisoxazoline, and Malonate: A Protocol for an Asymmetric Michael Reaction. J Org Chem. 2015 Jun 19;80(12):6336-41.
Kananovich DG, Konik YA, Zubrytski DM, Järving I, Lopp M. Simple access to β-trifluoromethyl-substituted ketones via copper-catalyzed ring-opening trifluoromethylation of substituted cyclopropanols. Chem Commun (Camb). 2015 May 14;51(39):8349-52.
Hansen K, Varvas K, Järving I, Samel N. Novel membrane-associated prostaglandin E synthase-2 from crustacean arthropods. Comp Biochem Physiol B Biochem Mol Biol. 2014 Aug;174:45-52.
Noole A, Ilmarinen K, Järving I, Lopp M, Kanger T. Asymmetric synthesis of congested spiro-cyclopentaneoxindoles via an organocatalytic cascade reaction. J Org Chem. 2013 Aug 16;78(16):8117-22.
Varvas K, Kasvandik S, Hansen K, Järving I, Morell I, Samel N. Structural and catalytic insights into the algal prostaglandin H synthase reveal atypical features of the first non-animal cyclooxygenase. Biochim Biophys Acta. 2013 Apr;1831(4):863-71.
Ausmees K, Kriis K, Pehk T, Werner F, Järving I, Lopp M, Kanger T. Diastereoselective multicomponent cascade reaction leading to [3.2.0]-heterobicyclic compounds. J Org Chem. 2012 Dec 7;77(23):10680-7.
Zari S, Kailas T, Kudrjashova M, Oeren M, Järving I, Tamm T, Lopp M, Kanger T. Organocatalytic asymmetric addition of malonates to unsaturated 1,4-diketones. Beilstein J Org Chem. 2012;8:1452-7.
Noole A, Järving I, Werner F, Lopp M, Malkov A, Kanger T. Organocatalytic asymmetric synthesis of 3-chlorooxindoles bearing adjacent quaternary-tertiary centers. Org Lett. 2012 Sep 21;14(18):4922-5.
Eek P, Järving R, Järving I, Gilbert NC, Newcomer ME, Samel N. Structure of a calcium-dependent 11R-lipoxygenase suggests a mechanism for Ca2+ regulation. J Biol Chem. 2012 Jun 22;287(26):22377-86.
Järving R, Lõokene A, Kurg R, Siimon L, Järving I, Samel N. Activation of 11R-lipoxygenase is fully Ca(2+)-dependent and controlled by the phospholipid composition of the target membrane. Biochemistry. 2012 Apr 17;51(15):3310-20.
